Updated December 16th, 2023 at 09:31 IST
Ketamine Infusion Therapy: Experimental treatment that Matthew Perry was undergoing for depression
Medical examiners cited drowning, coronary artery disease, and acute effects of ketamine as contributing factors to Matthew Perry's death.
- 2 min read
Friends fame Matthew Perry died on October 28, 2023.Medical examiners cited drowning, coronary artery disease, and acute effects of ketamine as contributing factors to his death. However, the autopsy report ruled out any external foul play. So, let’s delve into the details of ketamine and the infusion therapy Perry underwent a week and a half prior to his passing.
What is ketamine infusion therapy?
Infusion therapy is a medical procedure involving the direct administration of fluids, medications, or nutrients into a patient's bloodstream through intravenous (IV) access. This method ensures precise control over substance delivery, allowing for rapid absorption into the circulatory system.
Ketamine infusion therapy is a specialized application utilising ketamine, a dissociative anesthetic initially developed for surgical use. In recent years, ketamine has garnered attention for potential therapeutic applications beyond anesthesia, notably in the realm of psychiatry.
How does the therapy work?
Ketamine infusion therapy primarily targets mood disorders such as major depressive disorder (MDD), treatment-resistant depression (TRD), anxiety disorders, and post-traumatic stress disorder (PTSD). Unlike conventional antidepressants, which may take weeks to exhibit effects, ketamine often demonstrates rapid onset, sometimes within hours or days.
The exact mechanisms driving ketamine's antidepressant effects remain partly understood. However, it is thought to involve the modulation of glutamate, the brain's primary excitatory neurotransmitter. Ketamine interacts with N-methyl-D-aspartate (NMDA) receptors, promoting increased synaptic plasticity and the release of neurotrophic factors. These molecular alterations may contribute to observed antidepressant effects in select patients.
Concerns about the therapy
While ketamine infusion therapy shows promise, concerns about its long-term safety and efficacy have resurfaced following Matthew Perry’s unfortunate demise. Ongoing research aims to establish optimal dosing, frequency, and potential side effects. Patients contemplating ketamine infusion therapy are urged to consult healthcare professionals to discuss personalized treatment plans, potential risks, and alternative options.
Published December 16th, 2023 at 09:13 IST
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